UNC 926 hydrochloride

CAS No. 1184136-10-4

UNC 926 hydrochloride( —— )

Catalog No. M17174 CAS No. 1184136-10-4

UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 41 In Stock
10MG 71 In Stock
25MG 140 In Stock
50MG 250 In Stock
100MG 403 In Stock
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Biological Information

  • Product Name
    UNC 926 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3.
  • Description
    UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively and dose-dependently inhibits the L3MBTL13xMBT-H4K20me1 interaction. UNC-926 has not an effect on the binding of 53BP1 to H4K20me1.
  • In Vitro
    UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7.UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    L3MBTL1
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    1184136-10-4
  • Formula Weight
    373.72
  • Molecular Formula
    C16H21BrN2O·HCl
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 41.67 mg/mL (123.56 mM)
  • SMILES
    C1CCN(C1)C1CCN(CC1)C(=O)c1cc(ccc1)Br
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Herold JM, et al. Structure–activity relationships of methyl-lysine reader antagonists. MedChemComm. 2012;3(45):45–51.
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